Speech disorders reflect differing pathophysiology in Parkinson’s disease, progressive supranuclear palsy and multiple system atrophy | Semantic Scholar (2024)

Speech recordings revealed that deviant pause production differentiated between PSP, MSA, and PD and PSP showed greater deficits in speech respiration when compared to MSA and PD.

Objective speech assessment may provide an inexpensive and widely applicable screening instrument for differentiation of MSA and PD from controls and among subtypes of M SA.

The clinical-neurophysiological features of speech disorders identified in patients with different variants of parkinsonism may be of value in the differential diagnosis of these diseases and the development of approaches to rehabilitating patients.

Patients with atypical Parkinsonism showed a different strategy to intentionally improve their speech performance following a simple request to produce speech more clearly compared to PD, suggesting important therapeutic implications for speech rehabilitation management.

The clinical and neurophysiological features of speech disorders in patients with various variants of parkinsonism will be useful in the differential diagnosis of these diseases and can be used in developing approaches to patient rehabilitation.

MSA-P and PSP compared with PD were distinguished by severity of speech/voice deterioration, but individualspeech/voice parameters failed to consistently differentiate groups.

Because language impairment is often an early and persistent problem in CBS and PSP, there is a need for improved methods for language screening in primary and secondary care, and more detailed language assessments in tertiary healthcare settings.

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Dysarthria in PD, PSP and MSA have many overlapping but certain distinctive features as well which could serve as a diagnostic clue, and profound speech impairment probably indicative of the more severe frontostriatial pathology.

In idiopathic Parkinson's disease repetitive speech phenomena seem to emerge predominantly in a subgroup of patients with advanced disease impairment; manifest dementia is not a necessary prerequisite.

The finding of a mixed dysarthria with a combination of spastic, hypokinetic, and ataxic components might assist in diagnosis and is consistent with the widespread neuropathologic changes found in PSP.

A distinct variant of mixed dysarthria with a combination of hyperkinetic and hypokinetic components representing the altered motor programming of dystonia and bradykinesia in ephedrone-induced parkinsonism is revealed.

Specific speech alterations observed in HD patients indicate that speech production may reflect the pathophysiology of the disease as well as treatment effects, and may therefore be considered a valuable marker of functional disability in HD.

The hypokinetic dysarthria of progressive supranuclear palsy may result from degenerativeChanges in the substantia nigra pars compacta and pars reticulata and not from changes in the striatum or globus pallidus.

Although MSA and PSP differed quantitatively on the total score at entry and on rate of progression, the relative contribution of clinical dimensions to overall severity and progression was similar and therefore is appropriate for use in clinical studies with PSP or MSA.

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